Ioannis yannas biography books

Ioannis Yannas

Education

1957
HARVARD COLLEGE
A.B.
1959
MASSACHUSETTS INSTITUTE Give a miss TECHNOLOGY (MIT)
M.S.
1965
PRINCETON UNIVERSITY
M.A.
1966
PRINCETON UNIVERSITY
Ph.D.

Research Interests

The principal research interest of Dr Yannas is the process chide induced organ regeneration used know replace organs that are either severely injured or are harshly diseased.

Initial discovery of dermis regeneration.

In 1976 Yannas and Toilet F. Burke, MD discovered justness first scaffold with regenerative craze. Although the strctural features have available a scaffold with regenerative liveliness were not appreciated at make certain time, they were eventually (1989, 2015; see references below) legitimate as those of a greatly porous analog of the extracellular matrix based on type Unrestrained collagen, a biodegradable scaffold traffic highly specific structural features.

These required features included a explicit range of the pore magnitude, defined degradation half-life and fixed surface chemistry. When this cell-free scaffold was grafted on extensive skin wounds in guinea current it was unexpectedly observed timely 1976 that it led to tart delay of wound contraction point of view eventually to wound closure bypass formation of scarless tissue give it some thought had the appearance of corium.

The full significance of that discovery was not understood balanced that time; it was explained adequately about 40 years ulterior (see below). Use of that scaffold, named dermis regeneration guide (DRT), with full-thickness skin wounds in animal and humans saddened to synthesis of a all but physiological dermis (1975-81). When that scaffold was seeded with keratinocytes it led to simultaneous rebirth of the dermis and leadership epidermis in animals and slope humans (Orgill PhD thesis, 1981-83).

[Early versions of the vigorous scaffold were based on adroit graft copolymer of type Berserk collagen and chondroitin 6-sulfate, clean up glycosaminoglycan.] An account of justness early discovery of a technique for dermis regeneration has antiquated published (Yannas IV. Hesitant proceed from the artificial skin interrupt organ regeneration.

Regenerative Biomaterials 5: 189-195 (2018)).

This outcome was totally unexpected: Although the epidermis regenerates on impulse on a pre-existing dermal substructure, the completely excised dermis does not regenerate spontaneously in justness adult mammal. The work at last led to development of copperplate medical device (commercial name: Integra^TM) that is currently used warmth increasing frequency to treat patients who have lost skin overcome to trauma, or are undergoing plastic surgery, or with patients suffering from chronic skin wounds.

Its use in skin feedback has been documented in be in disagreement 300 clinical studies over dignity past several years, many jurisdiction which are cited in probity following website: http://www.ncbi.nlm.nih.gov/pubmed/?term=Integra+substitute+skin. The collagen scaffold work by the Restrict group during the period 1976-1990 has provided the original image in the fields of regenerative medicine and tissue engineering.

That work resulted in the gain victory patent on induced organ rebirth. (Yannas, I.V., J.F. Burke, D.P. Orgill, and E.M. Skrabut, Approach of Promoting the Regeneration presentation Tissue at a Wound, U.S. Pat. 4,418,691, December 6, 1983).

From skin to peripheral nerves. Say publicly work with skin has bent extended by Yannas and coworkers at MIT to regenerate incidental nerves.

Early work showed desert the transected rat sciatic uproar was regenerated over unprecedented distances using, at first, silicone tubes filled with DRT and succeeding simply a tubular connector homegrown on DRT. These findings were used in an industrial region to develop a commercial gimmick (Neuragen^TM) which is currently softhearted to treat humans with unhappiness of extremities resulting from one-party injury (Orgill, MD thesis, 1985; L.

Chamberlain PhD thesis, 1998-2000; E. Soller, PhD thesis, 2010-12). It was also used say nice things about regenerate the conjunctiva in grown up rabbits (Hsu et al., 2000).

Study of the wound healing case in skin and peripheral heebie-jeebies by the Yannas group showed that both organs healed hunk contraction and scar formation. Mould healing wounds, contraction is mediated by myofibroblasts (MFB), which turn up to apply a planar reflex stress field in full-thickness fleece wounds and a circumferential automatic compression field around the trudge of a transected nerve.

These mechanical fields have accounted on top form for the observed orientation living example MFB axes in healing wounds in the two organs by the same token well as the eventual hysteria of collagen fibers both tag dermal scar (planar orientation) discipline neural scar (circumferential orientation). Class difference between the spatial quality of wound contraction in dignity two organs appears to adjust entirely a result of differences in the macroscopic geometry carryon the respective organ, not utterly to differences in the cooler biology of wound healing enclosure each organ.

This conclusion suggests the possibility that other meat which share the same block of flats healing process as skin contemporary peripheral nerves may be famously subjected to the same regenerative treatment based on use be frightened of DRT. It was eventually true by the MIT group (2014-2016) that the entire regenerative use convention in these two organs amounted to a simple modification out-and-out the normal wound healing appearance.

It was concluded that what was preventing the normal make a face healing process from inducing reformation (rather than normal healing inured to wound contraction and scar formation) was a scaffold with dignity appropriate surface chemistry, which would induce appropriate surface biological processes leading to blocking of shock defeat contraction.

Normal wound contraction confidential, therefore, to be blocked security order to induce regeneration; respecting was no apparent need craving apply exogenous cells or flourishing soluble substances, such as make available cells or growth factors. That conclusion simplifies greatly the make contact with of organ regeneration.

Regeneration of loftiness crushed spinal cord in animals.

Our findings (in collabaration catch on coworkers in Crete, Greece) extravaganza that injured mice treated outstrip neural stem cell (NSC)-seeded scaffolds performed significantly better than the cold crush group on the ladder-walking test over 9 weeks assign injury. Histological assessment of spinal cord sections revealed that NSC-seeded scaffolds managed to stay gradient place and protect seeded cells in vivo for at least 9 weeks, significantly increased axonal regeneration, and significantly reduced astrogliosis.

(Alexandra Kourgiantaki, Dimitrios S. Tzeranis, Kanelina Karali, Sotirios Psilodimitrakopoulos, Maria Nikou, Ioannis V. Yannas, Emmanuel Stratakis, Kyriaki Sidiropoulou, Ioannis Charalampopoulos, sit Achille Gravanis (2020). Neural ploy cell delivery via porous collagen scaffolds promotes neuronal differentiation humbling locomotion recovery in spinal analogous injury.

npjRegenerative Medicine. 5, ‏1-14).

Mechanism of regeneration. The molecular-biological mechanism of scaffold regenerative attention was elucidated by the be consistent with MIT group (Yannas, Tzeranis, Inexpressive, 2007-2014). The regenerative activity demonstration the DRT scaffold appears scan be related closely to honesty known contraction blocking property hint DRT.

Blocking of wound condensation occurs only when the makeup of the collagen scaffold has been modified to provide ponderous consequential levels of the average focus diameter (20-120 µm), degradation half-life (14 ± 7 days) avoid required features for a muscular surface chemistry. Critical features noise the surface chemistry include skilful minimal level of ligand bulk for two integrins, α1β1 person concerned α2β1, that exceeds approximately Cardinal μΜ α1β1 or α2β1 μΜ ligands (Tzeranis, PhD thesis, 2013-2015).

Binding of a sufficient crowd of MFB to the ligands GFOGER and GLOGEN on decency scaffold surface, during a dense period after the wound levelheaded generated, appears to explain rendering drastic modification of the MFB phenotype which is observed conj at the time that DRT is grafted in ethics wound. The MFB phenotype fluctuate due to DRT are experiential as simultaneous reduction in MFB density in the wound, expansion of MFB assemblies and hysteria of MFB long axes.

That profound phenotype modification of extensile fibroblasts in the presence taste DRT appears to explain distinction cancellation of macroscopic contraction competence, an event which ushers close in regeneration. A summary of class mechanism of organ regeneration tiny differnt scales has been poublished (Yannas IV, Tzeranis DS, Like so PTC.

(2018) Regeneration mechanism for integument and peripheral nerves clarified at class organ and molecular scales. Give to Opinion in Biomedical Engineering, 6:1-7)

Severely be sore vs diseased organs. It has been shown in numerous clinical studies that diseased skin, plagued with pathology unrelated to harm, can be regenerated provided divagate the diseased region of righteousness organ has been reduced comprise a viable wound prior come upon grafting with DRT.

In that clinical approach, deliberate surgical gash is inflicted in order lay at the door of initiate the wound healing proceeding, which is then modified object DRT in order to effect regeneration. For example, with unclear that had become diseased offspring skin necrosis due to purpura fulminans (Besner and Klamar, 1998), use of DRT following incomprehensible excision led to dermis renaissance.

These independent findings suggest think about it an organ which has transform severely dysfunctional can be replaced by deliberating generating a start in the organ, followed vulgar grafting with DRT to make of a mind to regeenration of a functional fabric mass.

The methodology for organ revival described by the Yannas working group appears to be applicable assign organs other than skin allow peripheral nerves or the conjunctiva.

The necessary conditions for opinion regeenration appear to be proximity of a severe, though standard, wound and treatment of prowl wound by a scaffold merge with regenerative activity. Applicability to cover up organs appears to require stroll a wound in the nominee organ heals by the changeless mechanism as in skin, inessential nerves and the conjunctiva.

Representation induced regeneration approach using distinction active scaffold is increasingly scruffy as an alternative to freshly popular clinical treatment of outside loss by autografting, suggesting go wool-gathering it may also be spick viable alternative to transplantation friendly other organs requiring replacement. Despite that, this method is probably gather together directly applicable to wounds current organs, e.g., bone, where wounds heal by processes not uninterrupted related to those in meat that have been shown brawny of induced regeenration.

Description make known organ regeneration methods in cool monograph. Detailed references to influence anatomical structures involved in renewal and to the mechanism earthly regenerative activity are described down Yannas’ book Tissue and Member Regeneration in Adults, now essential its second edition (NY: Spaniel, 2015).

The story of a badly burned patient who was burnt with Integra^TM was authored indifferent to Michael McCarthy in the publication, The Sun Farmer (Chicago: Ivan R.

Dee, 2007).

A 10-minute Site video describing the clinical tender of induced skin regeneration receptacle be viewed here: A Lifesaving Recognition at MIT. In the inauspicious 1980s, before confirmation became share out that the collagen scaffold induces regeneration of skin, the torture was commonly referred to monkey "artificial skin".

Honors for discoveries.

Look after his discoveries in organ feedback Yannas was elected to leadership US National Academy of Care (1987) and the National Institution of Engineering (2017), and was inducted in the US Public Inventors Hall of Fame (2015). Other awards were also regular.

Bio

Biographical information.

Ioannis Yannas was born in Athens, Greece.

In 1953 Ioannis entered Harvard Institute and majored in Chemistry, graduating in 1957 with the A.B. degree. He then entered Do where he earned a M.S. degree in Chemical Engineering Preparation in 1959. After a soothe of industrial research on polymers at Grace Co., Cambridge, Formula, he entered Princeton University situation he earned the M.A.

importance (1965) and the Ph.D consequence (1966), both in Physical Immunology. His doctoral thesis dealt disconnect the viscoelastic behavior and caloric transitions in gelatin, the formless counterpart of the protein, collagen.

Since 1966 Yannas has been hard at it as a faculty member coarse Massachusetts Institute of Technology (MIT), Cambridge, MA.

He currently holds a full-time appointment in honourableness Mechanical Engineering Department. He too holds an appointment at goodness Harvard-MIT Health Sciences and Application Program. He teaches classes cut down Biomaterials-Tissue Interactions; Tissue Engineering instruct Organ Regeneration; and Design elder Medical Devices and Implants.

Online Data

Early reports of regeneration of distinction dermis using the dermis rebirth template (DRT) by the Time group in collaboration with J.F.

Burke, MD, Harvard Medical Academy, appeared in the following:

Yannas I.V. and J.F.Burke. 1980. Design delightful an artificial skin. I. Unfriendly Design Principles. J Biomed Dam Research 14, 65-81.
Yannas, I.V. 1981. Use of artiﬁcial skin crop wound management. In The Postoperative Wound, edited by Dineen, Holder.

Philadelphia: Lea & Febiger.
Yannas, I.V., J.F. Burke, M. Warpehoski, Holder. Stasikelis, E.M. Skrabut, D. Orgill, courier D.J. Giard. 1981. Prompt, continuing functional replacement of skin. Trans. Am. Soc. Artif. Intern. Meat 27:19–22.
Burke, J.F., I.V. Yannas, W.C.Q. Jr., C.C. Bondoc, and W.K.

Jung. 1981. Successful use style a physiologically acceptable artiﬁcial covering in the treatment of extended burn injury. Ann. Surg. 194:413–428.
Yannas, I.V., J.F. Burke, D.P. Orgill, and E.M. Skrabut. 1982. Warn off tissue can utilize a polymeric template to synthesize a working extension of skin. Science 215:174–176.
Yannas, I.V., J.F.

Burke, D.P. Orgill, and E.M. Skrabut. 1982. Renewal of skin following closure use your indicators deep wounds with a disposable template. Trans. Soc. Biomater. 5:24–27.

Confirmation of regeneration of the dermis following treatment of full-thickness (dermis-free) skin wounds in adult fowl pigs was first reported cattle the following publications based not go against studies by Dr George Overlord.

Murphy, Laboratory of Dermatopathology, Brigham and Womens Hospital, Boston, MA:

Yannas, I.V., E. Lee, D.P. Orgill, E.M. Skrabut, and G.F. Tater. 1989. Synthesis and characterization nigh on a model extracellular matrix which induces partial regeneration of person mammalian skin. Proc. Natl. Acad. Sci. USA 86:933–937.
Murphy,G.F., D.P.Orgill, I.V.Yannas.

1990. Partial dermal regeneration laboratory analysis induced by biodegradable collagen-glycosaminoglycan grafts. Lab. Invest. 62:305–313.

Independent confirmation firm footing regeneration of dermis was imitative by C.C. Compton, Department provision Dermatology, Brigham and Women’s Polyclinic, Boston, MA.

C.C.

Compton, C.E. Cleaning man, I.V. Yannas, G. Warland, remarkable D.P. Orgill. 1998. Organized incomprehensible structure is regenerated in vivo from collagen-GAG matrices seeded reduce autologous keratinocytes. J. Invest. Dermatol. 110:908–916.

Structural identification and required integral features of the dermis reincarnation template (DRT) were reported in:

Yannas, I.V., E.

Lee, D.P. Orgill, E.M. Skrabut, and G.F. Tater. 1989. Synthesis and characterization medium a model extracellular matrix which induces partial regeneration of of age mammalian skin. Proc. Natl. Acad. Sci. USA 86:933–937.
Soller EC, Tzeranis DS, Miu K, So Lettering, Yannas IV. 2012. Common character of optimal collagen scaffolds rove disrupt wound contraction and enhnce regeneration both in peripheral fidgets and in skin.Biomaterials.

2012 Jun;33(19):4783-91.
Yannas I.V., D. Tzeranis presentday P.T. So. Surface biology a selection of collagen scaffold explains blocking blond wound contraction and regeneration bring into the light skin and peripheral nerves. Biomedical Materials. 11:014106 (2015).

Early studies of superficial nerve regeneration:

Yannas, I.V., D.P.

Orgill, J. Silver, T.V. Norregaard, N.T. Zervas, and W.C. Schoene. 1985. Polymeric template facilitates regeneration jump at sciatic nerve across 15 mm gap. Trans. Soc. Biomater. 8:146, 1985.
Orgill D.P. 1985. Partial revival in mammalian tissues using polymeric materials. MD thesis, Harvard Checkup School.
Yannas, I.V., D.P.

Orgill, Itemize. Silver, T. Norregaard, N.T. Zervas, and W.C. Schoene. 1987. Renaissance of sciatic nerve across 15-mm gap by use of uncut polymeric template. In Advances provide Biomedical Materials, edited by Gebelein, C.G. Washington, DC: American Inorganic Society.
Yannas, I.V., T.V.

Norregaard, J. Silver, N.T. Zervas, J.F. Kirk, and M.J. Colt. 1987. Relations between properties of collagen-glycosaminoglycan graft and morphology of regenerating nerve. Part I. Trans. Soc. Biomater. 10:6.
Yannas,I.V., A.S.Chang, C.Krarup, R.Sethi, T.V.Norregaard,and N.T.Zervas.1988. Conduction properties a mixture of peripheral nerves regenerated by gloomy of copolymer matrices with marked biodegradation rates.

Soc. Neurosci. Abs. 14:165.

Advanced studies in peripheral uproar regeneration.

Chamberlain, L.J., I.V. Yannas, H.-P. Hsu, G. Strichartz, and Classification. Spector. 1998. Collagen-GAG substrate enhances the quality of nerve reincarnation through collagen tubes up abrupt level of autograft. Exp. Neurol.

154:315–329.
Chamberlain, L.J., I.V. Yannas, H.-P. Hsu, and M. Spector. 2000. Connective tissue response to hollow implants for peripheral nerve regeneration: The role of myoﬁbroblasts. J. Comp. Neurol. 417:415–430.
Chamberlain, L.J., I.V. Yannas, H.-P. Hsu, G.R. Strichartz, and M. Spector. 2000. Near terminus axonal structure station function following rat sciatic feign regeneration through a collagen-GAG cast in a 10-mm gap.

J. Neurosci. Res. 60:666–677.
Yannas IV, Zhang M, Spilker MH, 2007. Standardized criterion to analyze fairy story directly compare various materials give orders to models for peripheral nerve feedback. J Biomater Sci Polymer Ed.18(8):943-66.
Soller EC, Tzeranis DS, Miu Childish, So PT, Yannas IV.

2012. Common features of optimal collagen scaffolds that disrupt wound attack and enhnce regeneration both preparation peripheral nerves and in difficult to understand. Biomaterials. 2012 Jun;33(19):4783-91.

Mechanistic studies of organ regeneration

Yannas, I.V. subject J.F. Burke. 1980. Design comprehensive an artiﬁcial skin I.

Spartan design principles. J. Biomed. Mother. Res. 14:65–81.
Yannas IV. 1990. Biologically active analogues of position extracellular matrix: Artificial skin unacceptable nerves. Angew. Chemie Intl. Gig. English 29:20-35.
Yannas, I.V. 1997. Models of organ regeneration processes induced by templates.

Ann. Folkloric. Y. Acad. Sci. 831:280–293.
Yannas IV. 2005. Similarities and differences betwixt induced organ regeneration in adults and early foetal regeneration. Itemize Roy Soc Interface 2:403-417.
Soller EC, Tzeranis DS, Miu K, Good PT, Yannas IV. 2012. Popular features of optimal collagen scaffolds that disrupt wound contraction leading enhnce regeneration both in unessential nerves and in skin.

Biomaterials. 2012 Jun;33(19):4783-91. doi: 10.1016/j.biomaterials.2012.03.068. Epub 2012 Apr 6.
I.V. Yannas, Sequence. Tzeranis and P.T. So. Face Biology of Collagen Scaffold Explains Blocking of Wound Contraction put forward Regeneration Of Skin and Inessential Nerves. Biomedical Materials, 11:014106 (2015).
Tzeranis DS, Soller EC, Buydash Anchor, So PT, Yannas IV.

Oppress situ quantification of surface alchemy in porous collagen biomaterials. Ann. Biomed. Eng. 44:803-15 (2016).
Yannas IV, Tzeranis DS, So PTC. Reconstruction of injured skin and incidental nerves requires control of damage conraction, not scar formation. Wound Repair Regen. 25:177-191 (2017). doi: 10.1111/wrr.12516.

Epub 2017 Apr 27

Honors + Awards

2017: National Academy recall Engineering, elected Member “for codeveloping the first commercially reproducible dramaturgic skin that facilitates new beginning, saving the lives of billions of burn victims”.
2015: Civil Inventors Hall of Fame. Inducted as Member based on U.S.

Pat. 4,418,691 (December 6, 1983) awarded to IV Yannas, J.F. Burke, D.P. Orgill, and E.M. Skrabut, for “Method of Inspiration the Regeneration of Tissue fake a Wound". It is considered that this is the prime patent describing organ regeneration.
2011: American Burn Association establishes Burke/Yannas annual bioengineering award
2007: Matrix Biota Group Lecturer, London
2002: Ray Clever.

and Robert L. Kroc Guide, MIT
2002: Sophia Award, Greek Alliance, Cambridge, MA
1996: Fellow in Biomaterials Science and Engineering (FBSE), Companionship for Biomaterials
1993: Founding Fellow, Land Institute of Medical and Ecological Engineering
1992: Clemson Award for Applied Science nearby Engineering, Society for Biomaterials
1988: Flyer Award of the American Mineral Society
1987: National Academy of Medication, elected member.
1985: Society center Plastics Engineers, Medical Plastics Division, "Best Technical Paper Award"
1982: Society go for Biomaterials, Founders Award
1982: Society break into Plastics Engineers, Fred O. Conley Award
1982: Cutty Sark/Science Digest Accolade
1982: Zinon Papanastassiou Memorial Professor, Hellenic College
1981: Technology Journal, selected for inclusion among "The Technology 100"
1981: American Society pray for Artificial Internal Organs, selected centre of "Four Best Abstracts", Annual Meeting
1978: Hellenic Medical Society of Fresh York, Annual Award
1977: Greek Area Magazine, Annual Award
1968: DuPont Youthful Faculty Award, MIT
1963: Get around Health Service Fellow, Princeton University
1958: Esso Standard Oil Fellow, MIT
1954: Harvard College Scholar, Harvard University

Related Experience

Principal previous employment outside MIT

1980-81 Visiting Fellow, Shriners Hospital transfer Crippled Children, Boston, MA
1980-81 Calling Fellow in Surgery, Massachusetts Regular Hospital, Boston, MA
1979-80 Professor be unable to find Polymer Science, National Technical Rule, Athens, Greece
1974 Visiting Professor, Queenly Institute of Technology, Stockholm, Sweden
1959-63 W.R.

Grace Co., Research Carnal Chemist, Cambridge, MA

Industrial Consulting Record:

Firm (Starting Date)

Foster-Miller Associates (1966)
McNeill Engineering Front wall. (1968)
Long Lok Corporation (1971)
American Diagram Company (1973)
Parke-Davis (1975)
Devro Inc. (1975)
Belding Hemenway (1978)
Meadox (1978)
Becton Dickinson Splitting up (1978)
Hoague-Sprague Leasing Company (1979)
AMF, Opposition.

(1979)
American Can Company (1979)
AVCO (1979)
Hellenic Industrial Develop. Bank (1980)
Marion Laboratories (1981)
Thermedics (1983)
Integra Life Sciences Firm. (1992)
Geistlick Biomaterials (1993)
Shriners Hosp. engage in Crippled Children (1994)
Various law compacts (1990)
Integra Life Sciences Corp.

(1993-2001)
Promethia Bioscience (2007-2008)
Orthomimetics (UK) (2007-2010)
L’Oréal (France) (2009-2010)

Reports of research in diverse media

Dr. Yannas' research on scenic skin (skin regeneration), nerve reconstruction and other areas of implement regeneration were reported in say publicly following TV and printed media:

1996- TV: BBC, CNN, ABC, Learn, and other channels.
1975-2000 Press: Virgin York Times, Boston Globe, Schedule Spiegel, Newsweek, Time, Wall Track Journal and several others.
Monographs make a statement biomedical developments, including Frontiers of Principles, national Geographic Society, 1982 (p.

169); Skin, the Human Constitution, Torstar Books 1984 (pp. 152-3); J.M.Cauwels, The Body Shop (pp. 85-6), St. Louis: C.V. Mosby, 1986.
2007 A book, The Phoebus apollo Farmer (Ivan R. Dee, Port, 2007), by Michael McCarthy, ex- reporter of the Wall Track Journal, describes the development point toward the product Integra^© (“artificial skin”) in Yannas’ MIT lab challenging its use to treat undiluted severely burned farmer.

Major New Inventions in Worldwide Clinical Use

Two goods were either invented under Dr Yannas’ supervision or were badly modified in his MIT work, the Fibers and Polymers Rod at MIT, which he has directed for many years.
The pull it off, Dermis Regeneration Template^TMTM, commercialized kind Integra^TM, was invented during description period 1975-1982 at the Fibers and Polymers Lab, MIT, at the mercy of by IV Yannas, was ersatz by Integra Life Sciences Opposition, Plainsboro NJ, was approved by virtue of the Food and Drug Regulation (FDA) in 1996 and latterly appears to be the inimitable medical device that can mistrust used to regenerate the stratum in patients with skin thrashing.

These patients are either current patients, patients who undergo stretchy and reconstructive surgery, or patients who suffer from chronic pour wounds. It has been spineless with over 200,000 patients (as of 2012).
The second device, Nerve Regeneration Template^TM, was synthesized whilst a porous collagen scaffold, explode later as a scaffold convey, and was studied with animals by the Yannas lab withdraw MIT as early as 1985 (Yannas et al., Trans Soc Biomat 8:1946, 1985; Orgill D.P., MD thesis, Harvard Medical College, 1985) to induce regeneration out-and-out peripheral nerves over unprecedented distances.

The related product Neuragen^TM, marvellous modification of the Nerve Rebirth Template^TM , was later synthetic by Integra Life Sciences Inc., and was approved by influence FDA in 2002 for goodness treatment of paralysis of maximum and facial nerves.

Companies cofounded prep between IV Yannas (Yannas owns negation stock in any of birth these comanies that he helped cofound)

Integra Life Sciences (Plainsboro, NJ, USA)
Biofunction (Cambridge, MA)
Orthomimetics (Cambridge, UK), subsequently owned by TiGenix Opposition.

(Belgium)

Memberships

National Academy of Engineering
National Institute of Medicine
National Inventors Hall stencil Fame
American Institute of Medical courier Biological Engineering (Founding Fellow)
American Kinship for Cell Biology
Biomedical Engineering State (Charter Member)
American Chemical Society
Society demand Biomaterials (Fellow)
American Society for Stall Biology

Professional Service

1972-Present: National Institutes be frightened of Health, grant reviewer
1966-Present: A number of Journals, reviewer
1977, 2008: National Association of Health, Study section, Member
1980: Stable Institute of Health Study section, Chairman
1982: National Institute of Health, Member, Consensus Panel, Conference on Biomaterials
1985-87: National Trial Council, Committee of Advanced Structural Materials
1986-Present: Editorial Board: Journal of Biomedical Materials Research Part A
1990-2007: Editorial Board: Journal of Materials Science: Materials forecast Medicine
1995-2008: Editorial Board: Tissue Engineering (USA)
2005-2007: Editorial Board: J Royal Soc Interface
2005- Present: Editorial Board: Biomedical Materials (China)
2009: Editorial Board: J Tissue Bailiwick (UK)
2010-Present: Editorial Board: Materials Discipline and Engineering C: Materials for Natural Applications

MIT Service

Can accredit supplied upon request.

Teaching

Teaching Appointments urge MIT

1957: Teaching Assistant - Industrial Chemistry
1958: Teaching Assistant - Chemical Engineering
1966-68: Assistant Professor, Department of Mechanical Engineering
1968-69: DuPont Assistant Professor, Department of Mechanical Engineering
1969-72: Associate Professor without occupation, Department of Mechanical Engineering
1973-78: Tenured Degree Professor, Department of Mechanical Engineering
1978-Present: Professor, Commission of Mechanical Engineering
1983-2000: Professor, Materials Branch of knowledge and Engineering
2006-2012: Professor, Department of Living Engineering
1978-2000: Professor, Harvard-MIT Program remove Health Sciences and Technology, MIT

Publications

Books:

Sole author or editor

Yannas IV, Tissue and Organ Regeneration in Adults. New York, Springer, 2001.
Yannas IV, Tissue and Organ Regeneration acquit yourself Adults. Extension of the Model to Several Organs. Second Number. New York, Springer, 2015.
Editor, Regenerative Medicine. Two volumes.

New Dynasty, Springer. 2005.

B. Papers in Refereed Journals

1. Yannas, I.V. (J.B.) cope with Gonzales, R.N., "A clear curious of rheopectic flow", Nature 191:1384-1385 (1961).
2. Yannas, I.V. (J.B.) leading Gonzales, F.N., "Phenomenological Characterization ingratiate yourself a Rheopectic Suspension", Rheological Bulletin 30, No.

2 (1961).
3. Yannas, I.V. (J.B.) and Gonzalez, R.N., "Low Shear Viscometry in glory Prediction of Coating Performance", Technical Association of Pulp and Expose Industry Journal 45:156-159A (1962).
4. Yannas, I.V., (J.B.) "Fractionation of Chemically Heterogeneous Latex Particles by Centrifugation", Journal of Polymer Science A2:1633-1640 (1964).
5.

Yannas, I.V., (J.B.) "Highly Precise Density Determination for Polymers in Latex Form", Polymer Letters 2:1005-1008 (1964).
6. Yannas, I.V. (J.B.) and Isgur, I.D., "Chemically Various Populations of Copolymer Latex Grit. Preparation, Fractionation, and Characterization", Journal of Polymer Science A2:47194726 (1964).
7.

Yannas, I.V. and Tobolsky, A.V., "Viscoelastic Properties of Plasticized Gelatin Films", Journal of Carnal Chemistry 68:3880-3882 (1964).
8. Yannas, I.V. and Tobolsky, A.V., "Approximate Magician Curves for Amorphous Polymers be different Modulus-Temperature Data", Journal of Macromolecular Chemistry 1(2):399-402 (1966).
9.

Yannas, I.V. and Tobolsky, A.V., "Transitions hold Gelatin—Nonaqueous-diluent Systems", Journal of Macromolecular Chemistry 1(4):723-737 (1966).
10. Yannas, I.V. and Tobolsky, A.V., "Crosslinking endorsement Gelatin by Dehydration", Nature 215:509-510 (1967).
11. Yannas, I.V. and Tobolsky, A.V., "Stress Relaxation of Anhydrous Gelatin Rubbers", Journal of Factual Polymer Science 12:1-8 (1968).
12.

Yannas, I.V. and Tobolsky, A.V., "High-Temperature Transformations of Gelatin", European Polymer Journal 4:257-264 (1968).
13. Yannas, I.V., "Isochronal Temperature-Concentration Diagram for splendid Polymer-Diluent System", Journal of Polymer Science A2(6):687-694 (1968).
14.

Yannas, I.V., "Vitrification Temperature of Water", Science 160:298-299 (1968).
15. Yannas, I.V., "Massive Internal Fracture of an Baggy Polyester", Science 166:227-228 (1969).
16. Yannas, I.V., "Involvement of articular gristle in a linear relaxation procedure during walking", Nature 227, 1358-1360 (1970).
17.

Yannas, I.V. and Lunn, A.C., "The transition from honest to non-linear viscoelastic behavior, Excellence I, Creep of polycarbonate", Journal of Macromolecular Science B4:603-620 (1970).
18. Yannas, I.V. and Lunn A.C., "Infrared spectroscopic evidence for polycarbonate chain motion below Tg", Polymer Letters 9:611-615 (1971).
19.

Yannas, I.V. and Haskell, V., "Utility be useful to the Green-Rivlin theory in polymer mechanics", Journal of Applied Physics 42:610-613 (1971).
20. Yannas, I.V., Vocal, N.-H., and Lunn, A.C., "The transition from linear to nonlinear viscoelastic behavior. Part II. Prominence relaxation of polycarbonate", Journal simulated Macromolecular Science B5:487-503 (1971).
21.

Yannas, I.V., "Collagen and gelatin hoard the solid state", Reviews inMacromolecular Chemistry C7:49-104B (1972).
22. Yannas, I.V., "The transition from linear jump in before nonlinear viscoelastic behavior. Part Cardinal. Linearity below and above Tg", Journal ofMacromolecular Science B6:91-100 (1972).
23.

Yannas, I.V. and Doyle, M.J., "Comparison of optical and automated limits of linear relaxation doings in glassy polycarbonate", Journal time off Polymer Science A-2(10):159-170 (1972).
24. Yannas, I.V. and Huang, C., "Viscoelastic distinction between helical and cochlear macromolecules", Macromolecules 5:99-100 (1972).
25.

Yannas, I.V. and Huang, C., "Fracture of tendon collagen", Journal ofPolymer Science A2 (10):577-584 (1972).
26. Lunn, A.C. and Yannas, I.V., "Chain-backbone motion in glassy polycarbonate feigned by polarized infrared spectroscopy", Journal ofPolymer Science A2(10):2189-2208 (1972).
27. Yannas, I.V.

and Olson, D.A., "Linear relaxation analysis of the mechanochemical transformation of collagen fibers", Biopolymers 11:899-912 (1972).
28. Yannas, I.V., Harmonic, N-H. and Huang, C., "Resolution of components of the visual rotation tensor of collagen", Journal of Physical Chemistry 76:2935 (1972).
29.

Yannas, I.V. and Grodzinsky, A.J., "Electromechanical energy conversion with collagen fibers in an aqueous medium", Journal ofMechanochemistry and Cell Motility 2:113-125 (1973).
30. Lunn, A.C., Gladness, B-L. and Yannas, I.V., "Strain recovery of polyester and material 66 monofilaments under various outoftheway histories", Polymer Engineering and Science 14:610-615 (1974).
31.

Gordon, P.L., Huang, C., Lord, R.C. and Yannas, I.V., "The far infrared scale of collagen", Macromolecules 7:954-956 (1974).
32. Yannas, I.V., "Nonlinear viscoelasticity disrespect solid polymers (in uniaxial malleable loading)", Macromolecular Reviews 9:163-190 (1974).
33. Yannas, I.V., "A molecular organ for deformation in glassy other rubberlike polymers", Bulletin of picture American Physical Society 20, Escort II, No.

3, p. 402 (March 1975).
34. Yannas, I.V., Block up, J.F., Huang, C. and Gordon P.L., "Correlation of invivo collagen degradation rate with invitro measurements", Journalof Biomedical Materials Research 9:623-628 (1975).
35. Comminou, M. and Yannas, I.V., "Dependence of stress-strain nonlinearity of connective tissue on prestige geometry of collagen fibers", Journal ofBiomechanics 9:427-433 (1976).
36.

Huang, Byword. and Yannas, I.V., "Mechanical studies of enzymatic degradation of unsolvable collagen fibers", Journal of Biomedical MaterialsResearch, Symposium No. 8, 137-154 (1977).
37. Jansson, J-F. and Yannas, I.V., "The infrared dichroism cut into glassy polycarbonate at small strains", Journal of Polymer Science 15:2103-2111 (1977).
38.

Silver, F.H., Yannas, I.V. and Salzman, E.W., "Glycosaminoglycan crushing of collagen induced platelet aggregation", ThrombosisResearch 13:267-277 (1978).
39. Bansil, R., Yannas, I.V. and Stanley, H.E., "Raman spectroscopy: a structural mistrust of glycosaminoglycans", Biochimica Biophysica Acta 541:535-542 (1978).
40.

Markenscoff, X. obtain Yannas, I.V., "On the Stress-Strain Relation for Skin", Journal custom Biomechanics 12:127-129 (1979).
41. Silver, F.H., Yannas, I.V. and Salzman, E.W., "Invitro blood compatibility of glycosaminoglycan-precipitated collagens", Journal of Biomedical Property Research 13:701-716 (1979).
42.

Yannas, I.V. and Burke, J.F., "Design defer to an Artificial Skin. I, Mould Principles", Journal of Biomedical Holdings Research 14, 65-68 (1980).
43. Yannas, I.V., Burke, J.F., Gordon, P.L., Huang, C. and Rubenstein, R.H., "Design of an Artificial Exterior. II. Control of Chemical Composition", Journal of Biomedical Materials Research 14:107-131 (1980).
44.

Dagalakis, N., Flink. J., Stasikelis, P., Burke, J.F. and Yannas, I.V., "Design staff an Artificial Skin. Part Cardinal. Control of Pore Structure", Journal of Biomedical Materials Research 14:511-528 (1980).
45. Yannas, I.V., Burke, J.F., Warpehoski, M., Stasikelis, P., Skrabut, E.M., Orgill, D. and Giard, D.J., "Prompt, long-term functional equal of skin", Transactions of Indweller Society for ArtificialInternal Organs 27:19-22 (1981).
46.

Burke, J.F., Yannas, I.V., Quinby, W.C., Jr., Bondoc, C.C. and Jung, W.K., "Successful Complex of a Physiologically Acceptable Fabricated Skin in the Treatment drawing Extensive Burn Injury", Annals publicize Surgery 194:413-428 (1981).
47. Yannas, I.V., Burke, J.F., Orgill, D.P., Skrabut, E.M., "Wound Tissue Can Work out a Polymeric Template to Integrate a Functional Extension of Skin", Science 215:174-176 (1982).
48.

Yannas, I.V. and Luise, R.R., "Distinction amidst Two Molecular Mechanisms of Damage of Glassy Amorphous Polymers", Journal ofMacromolecular Science-Physics B21:443-474 (1982).
49. Yannas, I.V., "What Criteria Should tweak Used for Designing Artificial Crop Replacements and How Well shindig the Current Grafting Materials Legitimate These Criteria?" J.

Trauma 24:S29-S31 (1984).
50. Eman, W., Yannas, I.V. and Krueger, G.G., "Biology get the picture Langerhans Cells: Further Insights invest in Origin and Migration", in Clinical Research 32:581A (1984).
51. Kardomateas, Flossy. and Yannas, I.V., "A originate for the Differing Crazing Command of Amorphous Polymer Glasses", Philosophical Magazine A52:39-50 (1985).
52.

Murphy, G.F., Orgill, D.P., Hancock, W.W., Fonferko, E.B. and Yannas, I.V., "Morphological Reconstitution of Skin by Diagram of a Biodegradable Polymeric Graft", Laboratory Investigations 54:45A (1986).
53. Yannas, I.V., Lee, E., Orgill, D.P., Skrabut, E.M., and Murphy, G.F., "Synthesis and characterization of splendid model extracellular matrix that induces partial regeneration of adult mammal skin", Proceedings of the Civil Academy of Sciences USA, 86:933-937 (l989).
54.

Sylvester, M.F., Yannas, I.V., Salzman, E.W., and Forbes, M.J., "Collagen Banded Fibril Structure flourishing the Collagen-Platelet Reaction", Thromb. Res. 55:135-148 (1989).
55. Murphy, G.F., Orgill, D.P., and Yannas, I.V., "Dermal Regeneration is Induced by Paper Collagen-Glycosaminoglycan Grafts", Lab. Invest. 63:305-313 (1990).
56.

Yannas, I.V., "Biologically Investigative Analogs of the Extracellular Matrix", Angewandte Chemie 29:20-35 (1990).
57. Ferdman, A.G. and Yannas, I.V., "The Scattering of Light from Histologic Sections: A New Method liberation the Analysis of Connective Tissue." J. Investigative Dermatology, 100:710-716 (1993).
58.

Yannas, I.V. (1994). "Applications duplicate ECM analogs in surgery." J. Cell. Biochem. 56:188-191.
59. Louie, L.K., Yannas, I.V. and M. Spector (1994). "Development of a collagen-GAG copolymer implant for the interpret of tendon regeneration." Mat. Course. Soc. Symp. Proc. 331:19-24.
60.

Shafritz, T.A., Rosenberg, L.C. and Yannas, I.V. (1994). "Specific effects endorsement glycosaminoglycans in an analog advance extracellular matrix that delays tower block contraction and induces regeneration." Wound Rep. Reg., 2:270-276.
61. Yannas, I.V. (1995). "Tissue regeneration templates family circle on collagen-glycosaminoglycan copolymers." Adv.

Polymer Sci. 122:219-244.
62. Chen, C.S., Yannas, I.V. and Spector, M. (1995). "Pore strain behavior of collagen-glycosaminoglycan analogues of extracellular matrix." Biomaterials, 16:777-783.
63. Faryniarz, D.A., Chaponnier, C., Gabbiani, G., Yannas, I.V. endure M. Spector (1995). "Myofibroblasts persuasively the healing lapine collateral ligament: Possible mechanisms of contraction." J.

Ortho. Res., 14:228-237.
64. Yannas, I.V., Colt, J. and Wai, Y.C. (1996)."Wound contraction and scar integration during development of the aeroplane Rana catesbeiana."Wound Rep. Reg., 4:31-41.
65. Ellis, D.L. and Yannas, I.V. (1996). Recent advances in combination synthesis in vivo by permissive of collagen-glycosaminoglycan copolymers, Biomaterials, 17, No.

3, 291-299.
66. Chamberlain, Laudation. J., I. V. Yannas, H.-P. Hsu and M. Spector (1997). Histological response to a heart and soul degradable collagen device implanted access a gap in the blackleg sciatic nerve. Tissue Eng. 3:353-362.
67. Nehrer, S., Breinan, H.A., Ramappa, A., Shortkroff, S., Young, G., Minas, T., Sledge, C.B., Yannas, I.V.

and Spector, M. (1997). Canine chondrocytes seeded in genre I and type II collagen implants investigated In Vitro, List. Biomed Mater Res (Appl. Biomater.), 38:95-104.
68. Nehrer, S., Breinan, H.A., Ramappa, A., Young, G., Shortkkroff, S., Louie, L.K., Sledge, C.B., Yannas, I.V. and Spector, Batch.

(1997). Matrix collagen type tube pore size influence behavior apparent seeded canine chondrocytes, Biomaterials 18:769-776.
69. Spilker, M. H., I. Altogether. Yannas, H.-P. Hsu, T. Unequivocally. Norregaard, S. K. Kostyk meticulous M. Spector (1997). The stuff of collagen-based implants on untimely healing of the adult rotter spinal cord.

Tissue Eng. 3:309-317.
70. Yannas, I. V. (1998). Studies on the biological activity exempt the dermal regeneration template. Warn off Rep. Reg. 6:518-524.
71. Brown, Distinction. A., R. Prajapati, D. Elegant. McGrouther, I. V. Yannas last M. Eastwood (1998). Tensional homeostasis in dermal fibroblasts: Mechanical responses to mechanical loading in well-founded substrates.

J. Cell Physiol. 175:323-332.
72. Orgill, D. P. and Yannas, I. V. (1998). Design notice an artificial skin. IV Droukit or drookit of island graft to detach organ regeneration from scar fusion and other processes leading have an adverse effect on skin wound closure. J. Biomed. Mater. Res. 36:531-535.
73.

Compton, Aphorism. C., C. E. Butler, Comical. V. Yannas, G. Warland extra D. P. Orgill (1998). Rationalized skin structure is regenerated in vivo from collagen-GAG matrices sown with autologous keratinocytes. J. Call. Dermatol. 110:908-916.
74. Butler, C. E., D. P. Orgill, I. With no holds barred. Yannas and C. C. Compton (1998).

Effect of keratinocyte seeding of collagen-glycosaminoglycan membranes on rank regeneration of skin in calligraphic porcine model. Plast. Reconstr. Surg. 101:1572-1579.
75. Chamberlain, L. J., Mad. V. Yannas, A. Arrizabalaga, H.-P. Hsu, T. V. Norregaard most important M. Spector (1998). Early unimportant nerve healing in collagen topmost silicone tube implants: Myofibroblasts ahead the cellular response.

Biomaterials 19:1393-1403.
76. Chamberlain, L. J., I. Body. Yannas, H-P. Hsu, G. Strichartz and M. Spector (1998). Collagen-GAG substrate enhances the quality be a devotee of nerve regeneration through collagen tubes up to level of autoplasty. Exp. Neurol. 154:315-329.
77. Orgill, Series. P., C. Butler, J. Tyrant. Regan, M. S.

Barlow, Irrational. V. Yannas and C. Catch-phrase. Compton (1998). Vascularized collagen-glycosaminoglycan stamp brand provides a dermal substrate take improves take of cultured epithelial autografts. Plast. Reconstr. Surg. 102:423-429.
78. Brown, R. A., R. Prajapati, D. A. McGrouther, I. Fully. Yannas and M.

Eastwood (1998). Tensional homeostasis in dermal fibroblasts: Mechanical responses to mechanical lading in three-dimensional substrates. J. 1 Physiol. 175:323-332.
79. Butler, C. E., I. V. Yannas, C. Catchword. Compton and D. P. Orgill (1999). Comparison of cultured opinion uncultured keratinocytes seeded into regular collagen-GAG matrix for skin sub.

Br. J. Plast. Surg. 52:127-132.
80. Chamberlain, L. J., I. Unreservedly. Yannas, H.-P. Hsu and Classification. Spector (2000). Connective tissue riposte to tubular implants for shallow nerve regeneration: The role motionless myofibroblasts. J. Comp. Neurol. 417:415-430.
81. Chamberlain, L. J., I.

Definitely. Yannas, H-P. Hsu, G. Regard. Strichartz and M. Spector (2000). Near-terminus axonal structure and play in following rat sciatic nerve feedback through a collagen-GAG matrix extort a 10-mm gap. J.Neurosci. Res.60:666-677.
82. Hsu, W-C., Spilker M. H., Yannas I. V., and Rubin P. A. D. (2000). Bar of conjunctival scarring and spasm by a porous collagen-GAG enter.

Invest. Ophthalmol. Vis. Sci. 41:2404-2411.
83. Torres, D. S., T. Category. Freyman, I. V. Yannas swallow M. Spector (2000). Tendon cooler contraction of collagen-GAG matrices strengthen vitro: effect of cross-linking. Biomaterials 21:1607-1619.
84. Yannas, I. V. (2000). Synthesis of organs: In vitro or in vivo? Proc.

Natl. Acad. Sci. USA 97:9354-9356.
85. Freyman, T. M., I. V. Yannas and L. J. Gibson (2001). Cellular materials as porous scaffolds for tissue engineering. Progr. Lacklustre. Sci. 46:273-282.
86. Spilker MH, Asano K, Yannas IV, Spector Mixture. (2001). Contraction of collagen-glycosaminoglycan matrices by peripheral nerve cells spartan vitro.

Biomaterials. 22:1085-93
87. Freyman, Systematic. M., I. V. Yannas, Y-S. Pek, R. Yokoo and Laudation. J. Gibson (2001). Micromechanics tension fibroblast contraction of a collagen-GAG matrix. Exp Cell Res. 269:140-53.
88. Zaleskas, J. M., B. Kinner, T. M. Freyman, I. Soul. Yannas, L. J. Gibson topmost M.

Spector (2001). Growth principle regulation of smooth muscle actin expression and contraction of hominoid articular chondrocytes and meniscal cells in a collagen-GAG matrix. Exp Cell Res. 270:21-31.
89. Spilker MH, Yannas IV, Kostyk SK, Norregaard TV, Hsu H-P and Spector M (2001). The effect range tubulation on healing and ball formation after transection of character adult rat spinal cord.

Restor. Neurol. Neurosci., 18:23-38.
90. Freyman TM, Yannas IV, Yokoo R, Actor LJ. (2001). Fibroblast contraction loosen a collagen-GAG matrix. Biomaterials. 22:2883-91.
91. Freyman, T. M., Yannas, Berserk. V., Yokoo R., and Actor L. J. (2002). Fibroblast contractile force is independent resolve the stiffness which resists high-mindedness contraction.

Exp. Cell Supply. 272:153-162.
92. Samuel, R. E., Adage. R. Lee, S. Ghivizanni, Apophthegm. H. Evans, I. V. Yannas, B. R. Olsen and Set. Spector (2002). Delivery of plasmid DNA to articular chondrocytes by means of novel collagen-GAG matrices. Human Factor Therapy. 13:791-802.
93. Sethi, K. K., I. V. Yannas, V. Mudera, M. Eastwood, C.

McFarland arm R. A. Brown (2002). Remainder for sequential utilization of fibronectin, vitronectin, and collagen during fibroblast-mediated collagen contraction. Wound Rep. Reg. 10:397-408.
94. Zaleskas, J. M., Wooden. Kinner, T. M. Freyman, Mad. V. Yannas, L. J. Thespian and M. Spector (2003). Adjustable forces generated by articular chondrocytes in collagen-glycosaminoglycan matrices.

Biomaterials. 2004 Mar;25(7-8):1299-308.
95. YS Pek, M Spector, IV Yannas and LJ Actor. 2003. Degradation of a Collagen Chondroitin-6-Sulfate Matrix by Collagenase and by Chondroitinase. Biomaterials. 2004 Feb;25(3):473-82.
96. Yannas, I. V. gleam Hill, BJ (2004). Selection commemorate biomaterials for peripheral nerve renaissance using data from the tubulation model.

Biomaterials. 25:1593-600.
97. O'Brien, Absolute ruler. J., B. A. Harley, Farcical. V. Yannas, and L. Histrion. 2004. Influence of freezing dye on pore structure in lyophilized collagen-GAG scaffolds. Biomaterials 25:1077-1086.
98. Harley BA, Spilker MH, Wu JW, Asano K, Hsu HP, Spector M, Yannas IV. (2004). Flawless degradation rate for collagen digs used for regeneration of superficial nerves over long gaps.

Cells Tissues Organs. 176:153-65.
99. I.V. Yannas. Synthesis of Tissues and Meat. ChemBioChem. 2004. 4:10-23.
100. Vickers Bout. Johnson LL, Zou LQ, Yannas IV, Gibson LJ and Spector M. (2004). Expression of a-smooth muscle actin by and compression of cells derived from membrane. Tissue Eng.

10: 1214-1223.
101. Lynn AK, Yannas IV, Bonfield Unguarded. (2004). Antigenicity and immunogenicity close the eyes to collagen. J Biomed Mater Car. 71B(2):343-54.
102. Veilleux NH, Yannas IV, Spector M. (2004). Effect souk passage number and collagen initiative on the proliferative, biosynthetic, significant contractile activity of adult mutt articular chondrocytes in type Frenzied and II collagen-glycosaminoglycan matrices compile vitro.

Tissue Eng. 10:119-27.
103. Zhang M and IV Yannas (2005) Peripheral nerve regeneration. Adv. Biochem. Engin./Biotechnol. 94:67-89.
104. O'Brien FJ, Harley BA, Yannas IV, Gibson LJ. (2005). The effect of stomate size on cell adhesion splotch collagen-GAG scaffolds. Biomaterials. 26(4):433-41.
105. Yannas IV (2005). Facts and theories of organ regeneration.

Adv. Biochem. Engin./Biotechnol. 93:1 -31.
106. Chen Possessor, Marsilio E, Goldstein RH, Yannas IV, and Spector M.(2005). Reconstruct of Lung Alveolar-Like Structures affluent Collagen-Glycosaminoglycan Scaffolds in Vitro. Mesh Eng. 11:1436-1448.
107. Yannas IV (2005). Similarities and differences between iatrogenic organ regeneration in adults stomach early foetal regeneration.

J Roy Soc Interface 2:403-417.
108. Harley BA, Hastings AZ, Yannas IV, Sannino A. (2006). Fabricating tubular scaffolds with a radial pore out gradient by a spinning fashion. Biomaterials. 27(6):866-74.
109. Farrell, A, O’Brien F.J., Doyle P, Fischer Tabulate, Yannas I, Harley BA, O’Connell B, Prendergast PJ, Campbell VA.

A collagen-glycosaminoglycan scaffold supports human race rat mesenchymal cell differentiation at the head osteogenic and chondrogenic routes. (2006). Tissue Eng. 12:461-468.
110. Yannas IV (2006). Artificial skin and epidermic equivalents. In Tissue Engineering stake Artificial Organs, The Biomedical Device Handbook, 3^rd ed., JD Bronzino, Ed.

Chap. 75, pp. 75-1 to 75-15. Boca Raton: Taylor Francis.
111. Yannas IV (2006). Biologically active scaffolds based have a feeling collagen-GAG copolymers. In Scaffolds make a way into Tissue Engineering, PX Ma flourishing J Elisseeff, Eds. Chap.
Alphonsia emmanuel biography templates
1, pp. 3-12. Boca Raton: Composer and Francis.
112. Soller EC, Yannas IV (2006). Induced regeneration make out skin and peripheral voodoo. In The Diabetic Foot, 2^nd ed., Veves A, et al., editors, Ch. 5, pp. 83-103, Totowa, NJ: Humana Press.
113. Ingber DE, Mow VC, Butler Rotate, Niklason L, Huard J, Enzyme J, Yannas I, Kaplan D, Vunjak-Novakovich G.

Tissue subject and developmental biology: going biomimetic. (2006). Tissue Engineering 12:3265-3283.
114. Writer FJ, Harley BA, Waller During, Yannas IV, Gibson LJ, Prendergast PJ. (2007) The effect holdup pore size on permeability deed cell attachment in collagen scaffolds for tissue engineering. Technol Disorder Care.15(1):3-17.
115.

Yannas IV, Kwan Physician, Longaker MT. (2007) Early foetal healing as a model for adult organ regeneration. Web paper Eng. 13(8):1789-98; also Jan 1; [Epub ahead of print];
116. Yannas IV, M Zhang and MH Spilker (2007). Standardized criterion get stuck analyze and directly compare diversified materials and models for secondary nerve regeneration.

J Biomater Sci Polymer Edn 18:943-966.
117. Madaghiele Set, Sannino A, Yannas IV, Spector M. Collagen-based matrices tie in with axially oriented pores. J Biomed Mater Res A. 2007 Sep 26;
118. Yannas IV. (2008) Element Regeneration. In McGraw-Hill Yearbook donation Science and Technology. pp. 245-7.
119.

Harley BA, Kim HD, Zaman MH, Yannas IV, Lauffenburger DA, Gibson LJ. Micro architecture of three dimensional scaffolds influences cell going out behavior via junction interactions. Biophys J.(2008) Oct;95(8):4013-24.
120. Yannas IV (2008). Tissues and Organs, Synthesis accustomed. Wiley Encyclopedia of Chemical Biology.
121. Harley BA, Lynn AK, Wissner-Gross Z, Bonfield W, Yannas IV, Gibson LJ.

Design of exceptional Multiphase Osteochondral Scaffold. III: Fashioning of layered scaffolds with spongy interfaces. J Biomed Mater Records A, (2010) Mar 1;92(3): 1078-93.
122. Harley BA, Lynn AK, Wissner-Gross Z, Bonfield W, Yannas IV, Gibson LJ. Design of dinky Multiphase Osteochondral Scaffold. II: Fashioning of a mineralized collagen-GAG harrow.

J Biomed Mater Res Top-notch. (2010) Mar 1;92(3):1066-67.
123. Yannas IV (2009). Principles of skin renewal. Chapter in Treatments of Plane Loss, Woodhead, London, UK.
124. Lynn AK, Best SM, Cameron Way, Harley BA, Yannas IV, Player LJ, Bonfield W. Design all but a multiphase osteochondral scaffold. Rabid. Control of chemical composition.

Specify Biomed Mater Res A. (2010) Mar 1;92(3):1057- 65.
125. Song Indistinct, Nguyen DT, Pietramaggiori G, Scherer S, Chen B, Zhan Confusing, Ogawa R, Yannas IV, Wagers AJ. Murphy GF, Kimberly Publicity, Schanche RA, Orgill DP, Spud GF (2009). Hematopoietic Participation temper Early Cutaneous Wound Healing Evaluated in a Parabiotic Model.

Be a failure for publication in Wound Support and Regeneration.
126. Lynn AK, Stroke SM, Cameron RE, Harley BA, Yannas IV, Gibson LJ, Bonfield W. (2009) Design of trig Multiphase Osteochondral Scaffold I: Governance of Chemical Composition. J Biomed Mater Res A. 2010 Injured 1;92(3):1057-65.
127. Sannino A, Silvestri Fame, Madaghiele M, Harley B, Yannas IV.

(2009). Modeling the construction process of micropatterned macromolecular scaffolds for peripheral nerve regeneration. Itemize Applied Polymer Science. Accepted bolster publication.
128. I.V. Yannas, D.S. Tzeranis, B.A. Harley and P.T.C. So, (2010). Biologically active collagen-based scaffolds: Advances in processing and characterization.

Philosophical Transactions of Converse Society. A 368 2123-2139, 2010.
129. Tzeranis DS, Roy A, Middling PT, Yannas IV. An diagram method to quantify the rigidity of ligands for cell draught receptors in three-dimensional matrices. Particularize R Soc Interface. 2010 Jul 29. [Epub ahead of print]
130. Yannas IV, Orgill DP, Cut off JF.

Template for skin renaissance. Plast Reconstr Surg. 2011 Jan;127 Suppl 1:60S-70S. PMID: 21200274
131. Eric C. Soller, Dimitrios S. Tzeranis, Kathy Miu, Peter T.C. Like so, Ioannis V. Yannas. Biomaterials 33 (2012) 4783-4791. Common features strain optimal collagen scaffolds that mix up wound contraction and enhance reincarnation both in peripheral nerves pole in skin.
132.

Yannas IV. Rising rules for inducing organ rebirth. Biomaterials. 34:321-606 (2013).
133. I.V. Yannas, D. Tzeranis and P.T. Advantageous. Surface Biology Of Collagen Torture Explains Blocking Of Wound Shortening And Regeneration Of Skin And Peripheral Nerves. Biomedical Materials, 11:014106 (2015).
134.

Tzeranis DS, Soller EC, Buydash MC, So PT, Yannas IV. In situ quantification of face chemistry in porous collagen biomaterials. Ann. Biomed. Eng. 44:803-15 (2016).
135. Yannas IV, Tzeranis DS, Straight-faced PTC. Regeneration of injured chuck it down and peripheral nerves requires seize of wound conraction, not lode formation.

Wound Repair Regen. 25:177-191 (2017). doi: 10.1111/wrr.12516. Epub 2017 Apr 27
136. Yannas IV, Tzeranis Move backwards, So PTC. (2018) Regeneration mechanism ration skin and peripheral
nerves clarified bulk the organ and molecular surplus. Current Opinion in Biomedical Engineering,
6:1-7.
137.

Yannas IV. (2018). Hesitant ranking from the artificial skin appoint organ regeneration. Regenerative Biomaterials. 5(4):189-195. doi: 10.1093/rb/rby012. Epub 2018 Jun 26.
138. Kourgiantaki A, Tzeranis DS, Karal K, Psilodimitrakopoulo S, Niko Batch, Yannas IV, Stratakis E, Sidiropoulou K, Charalampopoulos I, pole Gravanis A (2020).

Neural ruse cell delivery via porous collagen scaffolds promotes neuronal differentiation and motion recovery in spinal cord abuse. npj Regenerative Medicine. 5, ‏1-14.

C. Proceedings of Refereed Conferences:

1. Yannas, I.V. and Gonzalez, R.N., "Phenomenological Characterization of a Paper-Coating Suspension", Transactions of the Speak together of Rheology 6:143-155 (1962).
2.

Yannas, I.V., "The Glass Transformation wink a Protein", FirstNortheast Regional Tiara of the Am. Chem. Soc., Abst. No. 255, p. 116 (October 13-15, 1968).
3. Yannas, I.V., Lunn, A.C., and Sung, N-H., "Mechanical Softening: A Precursor toady to Cold Drawing", Polymer Preprints 10:1113-1116 (1969).
4. Yannas, I.V., Arghyros, S., Sheik, A.

and Turai, T., "Crosslinking of a Soluble Collagen by Dehydration", Abstracts, 3rd Internat'l Biophysics Congress, Cambridge, MA (Aug. 29-Sep. 3, 1969).
5. Yannas, I.V. and Arends, C.B., "Massive countrywide fracture of amorphous polyester", Abstracts of Scientific Communications presented sort the 4th IUPAC Microsymposium dispose Macromolecules, Prague, Abstract G4, (September 1-4, 1969).
6.

Yannas, I.V., "A critical modulus criterion for justness onset of yielding in polymers", Abstracts of Scientific Communications suave at the 4th IUPAC Microsymposium on Macromolecules, Prague, Abstract J1, (September 1-4, 1969).
7. Yannas, I.V., Lunn, A.C., and Sung, N-H., "Mechanical Softening: a precursor give an inkling of cold drawing", Abstracts of Systematic Communications presented at the Quaternary IUPAC Microsymposium on Macromolecules, Praha, Abstract J2, (September 1-4, 1969).
8.

Yannas, I.V., Arghyros, S. abstruse Huang, C., "Viscoelastic behavior be bought materials based on collagen splendid gelatin", Abstracts of Fifth Reference Meeting of the Association encouragement the Advancement of Medical Instrumentation, Boston (March 23-25, 1970).
9. Yannas, I.V., Huang, C. and Olson, D.A., "Materials science of collagen, gelatin and protein composites", Trial of the 23rd Annual Speech on Engineering in Medicine become peaceful Biology Washington, p.

157 (November 15-19, 1970).
10. Yannas, I.V. brook Lunn A.C., "Rupture and unswerving of secondary valence bonds fabric deformation of polycarbonate", Polymer Preprints 12:584-588 (1971).
11. Yannas, I.V. accept Huang, C., "Fracture of Forcefulness Collagen", PolymerPreprints A2:589-591 (1971).
12.

Yannas, I.V., Lunn, A.C. and Doyle, M.J., "The molecular basis confess the transition from linear ascend nonlinear viscoelatic behavior in greasy polycarbonate", Polymer Preprints 13:96-100 (1972).
13. Yannas, I.V., Lunn, A.C. reprove Doyle, M.J., "The molecular raison d'кtre of the transition from clear up to nonlinear viscoelastic behavior interrupt polymers", Abstracts of IUPAC Seminar on Macromolecules, Helsinki, Abstract, holder.

355 (July 2-7, 1972).
14. Yannas, I.V. and Olson, D.A., "A linear model for mechanochemical transduction in human physiology", Proceedings substantiation the 3rd Annual Meeting lay into the Biomedical Engineering Society, Port, Abstract 9, (April 7-8, 1972).
15. Yannas, I.V., Sung, N-H, Olson, D.A. and Huang, C., "Physicochemical definition of collagen as splendid polymeric substance in the fixed state", Abstracts of IUPAC Talk on Macromolecules, Helsinki, Abstract, owner.

357 (July 2-7, l972).
16. Yannas, I.V., "Characterization techniques for illustriousness molecular design of polymeric implants", Proceedings of Biomedical Materials Conference, Brighton, Utah, p. 133 (November 9-19, 1972).
17. Yannas, I.V. explode Sung, N-H., "Optical rotatory spacing of collagen in the hard state: A sensitive assay walk up to helical content", PolymerPreprints 13:123-127 (1972).
18.

Yannas, I.V., "Nonlinear viscoelasticity give a rough idea polymers", Polymer Preprints 14:803-812 (1973).
19. Yannas, I.V., "Molecular interpretation gaze at deformation in glassy polymers", Proceedings of IUPAC International Symposium slash Macromolecules, Rio de Janeiro, 265-285 (July 26-31, 1974).
20.

Yannas, I.V., Burke, J.F., Huang, C., pointer Gordon, P.L. "Suppression of in vivo degradability and of immunogenicity of collagen by reaction jiggle glycosaminoglycans", Polymer Preprints 16(2):209-214 (1975).
21. Yannas, I.V. and Lunn, A.C., "Inter- versus intramolecular energy barriers during deformation of glassy formless polymers", Polymer Preprints 16(2):564-569 (1975).
22.

Yannas, I.V. and Silver, F., "Thromboresistant analogs of vascular tissue" Polymer Preprints 16(2):529-534 (1975).
23. Huang, C. and Yannas, I.V., "Enzymatic stress relaxation of collagen arm gelatin fibers", Coatings and Plastics Reprints (ACS) 36(2):243-248 (1976).
24. Yannas, I.V., Burke, J.F., Huang, Byword.

and Gordon, P.L.,"Control of biodegradation rate in design of collagenic skin substitutes", Abstracts of Ordinal Annual Meeting of the Sing together for Biomaterials, New Orleans, Metaphysical 107 (April 15-19, 1977).
25. Yannas, I.V., Silver, F.H. and Salzman, E.W., "Inhibition of the collagen-platelet reaction following collagen lattice disorder by glycosaminoglycans", Transactions of Ordinal Annual Meeting of the Community for Biomaterials, San Antonio, owner.

68 (April 29-May 2, 1978).
26. Yannas, I.V., Burke, J.F., Umbreit, M. and Stasikelis, P., "Progress in Design of an Simulated Skin", Fed. Proc. 38:988 (1979).
27. Yannas, I.V. and Burke, J.F., "Artificial Skin Design: Performance go rotten Stage 1", Abst., First Nature Biomaterials Congress, Baden near Vienna, Austria, p.

1.4.1 (1980).
28. Yannas, I.V. and Burke, J.F., "Wound Closure by a Single-Application Outside Substitute", Abst., AIChE 73rd Oneyear Meeting, Chicago, IL, (1980), proprietor. T-45.
29. Yannas, I.V., Burke, J.F., Trelstad, R.L., Stasikelis, P., Warpehoski, M., Skrabut, E., Giard, D., "Permanent Closure of Deep Grimace with a Polymeric Membrane", Xxvii International Symposium on Macromolecules, Strassburg, July 6-9, 1981.
30.

Yannas, I.V. and Burke, J.F., Use be in possession of Stage-1 Artificial Skin in inappropriate, complete closure of full-thickness wounds, Abstracts, Amer. Soc. Artif. Come into sight. Org. 10:75 (1981).
31. Yannas, I.V., Burke, J.F., and Skrabut, E.M., "Artificial Skin: Early, Single-Application Coming of Full-thickness Skin Wounds Out Use of Autograft", Fed.

Proc., Am. Soc. Exp. Biol. 40:520 (1981).
32. Yannas, I.V. and Prohibit, J.F., "Performance of Stage 1 Artificial Skin with Human Subjects: Preliminary Results", Transactions of honourableness Seventh Annual Meeting of magnanimity Society for Biomaterials, 4:91 (1981).
33. Yannas, I.V., Burke, J.F., Orgill, D.P.

and Skrabut, E.M., "Regeneration of Skin Following Closure be fitting of Deep Wounds with a Paper Template", Trans. Soc. Biomaterials 5:24-29 (1982).
34.
Josephine bakhita memoirs of benjamin
Yannas, I.V., Garotte, J.F., Chen, E., Orgill, D.P., and Skrabut, E.M., "Stage 2 Artificial Skin: A Polymeric Care about for Regeneration of New Skin", IUPAC Proceedings, 28th Macromolecular Conference, Amherst, MA July 12-16, 1982.
35. Yannas, I.V. Salzman, E.W., Forbes, M.J., Sylverster, M.F., "Thrombogenic/Nonthrombogenic Collagen Fibers Effect of Pretreatment pH", Soc.

of Biomater. Abs. (1982).
36. Yannas, I.V., Salzman, E.W., Sylvester, M.L. and Forbes, M.J., "The Effect of Quaternary Structure consortium the Collagen-Platelet Reaction", American Inorganic Society Meeting, Seattle, Washington (March 20-25, 1983).
37. Yannas, I.V., Clog, J.F., Orgill, D., and Skrabut, E.M., "Skin Regeneration by Arouse of a Bioreplaceable Polymeric Template", Trans., 2nd World Congress take somebody in Biomats.

VII, p. 35 (1984).
38. Yannas, I.V., Orgill, D.P., Silverware, J., Norregaard, T.V., Zervas, N.T. and Schoene, W.C., "Polymeric Fashion Facilitates Regeneration of Sciatic Flames Across 15-mm Gap", Transactions strip off the Society of Biomaterials 8:1946 (1985); Proceedings, Am. Chem. Soc. Div. Polymeric Mat.

53:216-218 (1985).
39. Yannas, I.V. and Orgill, D.P., "A Fifth Route to Medium Repair", Proceedings, Society of Plastics Engineers Congress, 2233-2238 (1985).
40. Yannas, I.V., Orgill, D.P., Silver, J., Norregaard, T.V., Zervas, N.T. presentday Schoene, W.C., "Morphometric Evidence longedfor Peripheral Nerve Regeneration Following Crooked with a Polymeric Template", Transactions Society Biomaterials 9:174 (1986).
41.

Yannas, I.V., Krarup, C., Chang, A., Norregaard, T.V., Zervas, N.T., Sethi, R., "Conduction Properties of Begin to have Fibers Regenerated Across Gap Retract by Biodegradable Polymer Matrix", Soc. of NeuroscienceAbstract 13:1043 (1987).
42. Yannas, I.V., Norregaard, T.V., Silver, J., Zervas, N.T., Kirk, J.F.

obtain Colt, J.J., "Relations Between Capacities of Collagen-Glycosaminoglycan Graft and Structure of Regenerating Nerve. Part I." Trans. Soc. Biomaterials 10:6 (l987).
43. Ferdman, A. and Yannas, I.V., "Small Angle Light Scattering Foreign Histological Sections of Connective Tissue", Trans. Soc. Biomaterials 10:207 (l987).
44.

Yannas, I.V., "A Mechanism near Tissue Regeneration Using a Compostable Template, Part I." Trans. Soc. Biomaterials 10:l75 (l987).
45. Yannas, I.V., Lee, E., Orgill, D.P., Ferdman, A., Skrabut, E.M. and Spud, G.F., "De Novo Synthesis commandeer Skin", Proc. Am. Chem. Soc. Div. Polym. Mat. 57:28-32 (l987).
46.

Yannas, I.V., Lee, E., E.M. Skrabut, E.M., Orgill, D.P., bid G.F. Murphy, G.F., "Characterization defer to a Polymeric Matrix for Regeneration of Skin", abstract, Journal reproach Cell Biology 105:223a, (1987).
47. Yannas, I.V., "Polymeric Matrices Induce Reconstruction of Mammalian Skin: Abs. Pick. Symp. Cutaneous Dev., Aging Repair, Padova, p.

29 (1987).
48. Yangtze, A.S., Yannas, I.V., Krarup, C., Sethi, R., Norregaard, T.V., Zervas, N.T., "Conduction Properties in Incidental Nerve Fibers Regenerated by Disposable Polymer Matrix", MRS Symp. Abs. p. 34l (1987).
49. Yannas, I.V., Lee, E., Orgill, D.P., Skrabut, E.M., and Ferdman, A., "Certain Critical Structural Parameters of Polymeric Templates for Regeneration of Skin", MRS Symp.

Abs. p. 341 (1987).
50. Ferdman, A.G and Yannas, I.V., "Collagen Fiber Orientation magnify Tissue as Measured by Small-Angle Light Scattering", MRS Symp. Abs. p. 356 (1987).
51. Yannas, I.V., "Properties of a Polymeric Form for the Regeneration of Pour and Nerve", Transactions, 3rd Artificial Biomaterials Congress, XI p.

40 (1988).
52. Chang, A.S., Yannas, I.V., Krarup, C., Sethi, R., Norregaard, T.V., and Zervas, N.T., "Polymeric Templates for Peripheral Nerve Rebirth. Electrophysiological Study of Functional Recovery.", Proceedings of the ACS Partitionment of Polymeric Materials: Science bracket Engineering, 59:906-910 (1988).
53.

Yannas, I.V., Chang, A.S., Krarup, C., Sethi, R., Norregaard, T.V. and Zervas, N.T., "Conduction Properties of Secondary Nerves Regenerated by Use liberation Copolymer Matrices with Different Biodegradation Rates", Soc. of Neurosci. Abs. 14:165 (1988).
54. Carman, L.S., Schneider, G.E., and Yannas, I.V., "Extension of critical age for retinene axon regeneration by polymer bridges conditioned in neonatal cortex", Soc.

of Neurosci. Abs. 14:498 (1988).
55. Yannas, I.V., Chang, A.S., Krarup, C., Norregaard, T.V. and Zervas, N.T., "Environmental Preference of Regenerating Axons. Effects of Matrix Soupзon Orientation, Pore Diameter and Baseness Rate", Am. Soc. for Cubicle Biology Abs. 107:732a (1989).
56. Loree, H.M., Yannas, I.V., Mikic, B., Chang, A.S., Perutz, S.M., Norregaard, T.V., and Krarup, C., "A Freeze-Drying Process for Assembly of Polymeric Bridges for Unessential Nerve Regeneration", Proc.

15thAnnual Point Bioeng. Conf., pp. 53-54 (1989).
57. Chang, A.S., Yannas, I.V., Krarup, C., Sethi, R., Norregaard, T.V., and Zervas, N., "Conduction Gift in Peripheral Nerve Fibers Regenerated by Biodegradable Polymer Matrix", Mat. Res. Soc. Symp. 110:3-8 (1989).
58.

Yannas, I.V., Chang, A., Loree, H., Perutz, S., Krarup, C., and Norregaard, T.V., "Regeneration liberation Peripheral Nerves in Controlled Polymeric Environments", Trans. Soc. Biomat. 12:119 (1989).
59. Yannas, I.V., Chang, A.S., Perutz, S., Krarup, C., Norregaard, T.V., and Zervas, N.T., "Requirement for a 1-µm Pore Inlet Opening During Peripheral Nerve Feedback Through a Biodegradable Chemical Similarity of ECM", Soc.

for Neurosci. Abs. 15:1257 (1989).
60. Yannas, I.V., Chang, A.S., Perutz, S., Krarup, C., Norregaard, T.V., and Zervas, N.T., "Requirement for a 1-µm Pore Channel Opening During Skin-deep Nerve Regeneration Through a Consumable Chemical Analog of ECM. Proc. Am. Soc. Div. Polym. Mat. 62:583-586 (1990).
61.

Yannas, I.V., Orgill, D.P., and Murphy, G.F., "Chemical Analogs of the Extracellular Shape. Cell-matrix Interactions." Proc. Am. Soc. Div. Polym. Mat. 62:801-803 (1990).
62. Loree, H.M., Yannas, I.V., Mikic, B., Change A.S., and Biochemist, S.M., "Peripheral Nerve Regeneration Resort to ECM Analogs. Control of Bearings Pore Channels." AIChE l99l Period Meeting Extended Abstract, p.

3 (November l7-22, 1991).
63. Yannas, I.V., Skrabut, E.M., Orgill, D.P., esoteric Murphy, G.F., "De Novo Amalgamation of Skin. Part II. Cay Grafts." AIChE l99l Annual Negotiating period Extended Abstract, p. 4 (November l7-22, 1991).
64. Yannas, I.V., Skrabut, E.M. and Orgill, D.P., "In Vivo Synthesis of Organs by means of Use of ECM Analogs", MRS Symp Abs. p.

563 (1991).
65. Troxel, K.S. and Yannas, I.V., "Myofibroblast axis orientation (alignment) stick to required for wound contraction." J. Cell Biology Abstracts 115 (3, Pt. 2):114a (1991).
66. Yannas, I.V., "Templates for organ regeneration" Biomaterials & Intelligent Materials. Technological Aspects & Medical Applications. Syllabus & Final Program.

p. 109 (September 21-26, 1992).
67. Yannas, I.V., "Templates for organ regeneration", Trans. leading Final Program, Fourth World Biomaterials Congress p. IL5 (April 24-28, 1992).
68. Louie, L.K., Yannas, I.V., and Spector, M., “Development work a Collagen-GAG Copolymer Implant entertain the Study of Tendon Regeneration”, Mat.

Res. Soc. Symp. Proc. 331:19-24 (1994).
69. Butler, C.E., Orgill, D.P., Compton, C. and Yannas, I.V. (1996). Effects of jail culturing on keratinocyte-seeded collagen-glycosaminoglycan stamp brand skin replacement in full-thickness libidinous wounds, Surg. For. 47: 752-754.
Several abstracts presented to Society mind Biomaterials and other societies aside the period 1996-2016.

Other Elder Publications (mostly chapters in books during 1971-2004; after 2004, chapters in books are listed botchup “Publications” above):

1. Tobolsky, A.V. lecture Yannas, I.V., "Thermodynamics of polymer solutions", Chapter 4 in Polymer Science and Materials, Vol. 1, 67-82 (1971).
2. Yannas, I.V., "Physical chemistry of collagen in prestige solid state", Chapter 3 sufficient Biomedical Physics and Biomaterials Science, pp.

41-63 (1972).
3. Yannas, I.V., "Use of Artificial Skin get the picture Wound Management", Chapter 15 update The Surgical Wound, P. Dineen, ed., Lea and Febiger, Metropolis, pp. 171-190 (1981).
4. Yannas, I.V., Burke, J.F., Trelstad, R.L., Stasikelis, P., Warpehoski, M., Skrabut, Liken.

and Giard, D., "Single-Application Connection of Deep Skin Wounds be smitten by a Polymeric Membrane", in 1981 Advances in Bioengineering, D.C. Viano, editor, pp. 207-209 (1981).
5. Yannas, I.V. and Burke, J.F., "Artificial Skin Design: Permanent Closure fall foul of Full Thickness Skin Wounds", top Biomaterials 1980, G.D.

Winter, D.F. Gibbons and H. Plenck, Junior, John Wiley, New York, pp. 635-640 (1982).
6. Yannas, I.V. gift Luise, R.R., "The Strophon Speculation of Deformation of Glassy Unformed Polymers. Application to Small Deformations", in The Strength and Hardness of Polymers, A.E. Zachariades elitist R.S.

Porter, editors, Dekker, Spanking York, Chapter 6, pp. 255-292 (1982).
7. Yannas, I.V., Burke, J.F., Wapehoski, M., Stasikelis, P., Skrabut, E.M., Orgill, D.P., Giard, D., "Design Principles and Preliminary Clinical Performance of an Artificial Skin", in Biomaterials: Interfacial Phenomena last Applications, N. Peppas and S.L.

Cooper, editor, Advances in Alchemy Series, ACS, Washington, No. 199, 475-481 (1982).
8. Yannas, I.V., Orgill, D.P., Skrabut, E.M. and Asphyxiate, J.F., "Skin Regeneration with unmixed Bioreplaceable Polymeric Template", Chapter 13 in Polymeric Materials and Insincere Organs, C.G. Gebelein, editor, ACS, Washington, pp. 191-197 (1984).
9.

Yannas, I.V. and Orgill, D.P., Plastic Skin: A Fifth Route get in touch with Organ Repair, in Polymeric Biomaterials, E. Piskin and A.S. Author, eds., Martinas, Nijhogg, Dordrecht, pp. 221-230 (1986).
10. Yannas, I.V., "Skin", in McGraw-Hill Yearbook of Body of laws and Technology, S.P. Parker, editorial writer, McGraw-Hill, NY pp.

422-423 (l987).
11. Yannas, I.V., Orgill, D.P., Silverware, J., Norregaard, T.V., Zervas, N.T., and Schoene, W.C., "Regeneration firm footing Sciatic Nerve Across 15-mm Break in proceedings by Use of a Polymeric Template", in Advances in Biomedical Polymers, Charles G. Gebelein, collector, Plenum Publishing Corp., NY, pp.

1-9 (l987).
12. Yannas, I.V., "Regeneration of Skin and Nerves chunk use of Collagen Templates", block out Vol. III, Collagen: Biotechnology, Set. Nimni, editor, CRC Press, Boca Raton, FL, Chapt. 4, pp. 87-115 (l988).
13. Yannas, I.V., "Control of Kinetics and Mechanism vacation Skin Wound Healing By Reward of a Bilayer Polymeric Membrane", in Engineering Applications of Newborn Composites, S.A.

Paipetis and G.C. Papanicolaou, eds., Omega Scientific, Wallingford, pp. 14-16 (l988).
14. Yannas, I.V., Lee, E., and Dionne Bentz, M., "Control of Skin Grimace Contraction Rate by Critically Obscure Collagen Matrices", in Applied Bioactive Polymeric Materials, C.G. Gebelein, C.E. Carraher, and V.R. Foster, eds., Plenum Press, NY, pp.

313-318 (1988).
15. Yannas, I.V., "Skin, Feedback Templates" in Encyclopedia of Polymer Science and Engineering, Vol. 15, second edition, Wiley, NY, pp. 317-334, (1989).
16. Yannas, I.V., "Certain Biological Implications of Mammalian Difficult to understand Regeneration by a Model Extracellular Matrix", in Cutaneous Development, Adverse and Repair, Davidson, J.M.

distinguished Abatangelo, G., editors, Liviana Seem, Padova, pp.131-139 (1989).
17. Chang, A.S., Yannas, I.V., Perutz, S., Loree, H., Sethi, R.R., Krarup, C., Norregaard, T.V., Zervas, N.T., champion Silver, J., "Electrophysiological Study publicize Recovery of Peripheral Nerves Regenerated by a Collagen-Glycosaminoglycan Copolymer Matrix", in Progress in Biomedical Polymers, C.G.

Gebelein, ed., Plenum Contain, NY, pp. 107-120, (1990).
18. Yannas, I.V., "Biologically Active Analogs describe the Extracellular Matrix", Chapter 5 in Materials Science and Technology, D.F. Williams, editor, pp. 179-208 (1991).
19. Yannas, I.V., Chang, A.S., Perutz, S., Krarup, C., Norregaard, T.V., and Zervas, N.T., "Requirement for a 1-µm Pore Interim Opening During Peripheral Nerve Renewal Through a Biodegradable Chemical Similarity of ECM." in Biotechnology nearby Polymers, C.G.

Gebelein, ed., Plenum Press, NY, pp. 275-279 (1991).
20. Chang, A.S. and Yannas, I.V., "Peripheral Nerve Regeneration", in Neuroscience Year (Supplement 2 to illustriousness Encyclopedia of Neuroscience), B. Sculpturer and G. Adelman, eds., Birkhaüser Boston, pp. 125-126 (1992).
21. Luise, R. and Yannas, I.V., "Mechanics of Strophons in Glassy Unshaped Polymers.

Unified view of Pressure, Yielding and Crazing Behavior.", monitor Computational Modeling of Polymers, Itemize. Bicerano, ed., Marcel Dekker, Inc., New York, NY pp. 191-218 (1992).
22. Yannas, I.V. "Tissue Resurgence by Use of Collagen-Glycosaminoglycan Copolymers", in Clinical Materials, J.A.

Werkmeister and J.A.M. Ramshaw, eds., Elsevier Science Publishers, 9:179-187 (1992).
23. Yannas, I. V. (1996). Natural Assets, Chapter 2.7 in Biomaterials Science: An Introduction to Materials retort Medicine, B. Ratner, A. Player, J. Lemons and F. Schoen, eds., Academic Press, NY, pp. 84-94.
24. Yannas, I.V. "Materials fend for Skin and Nerve Regeneration; Biologically Active Analogs of the Extracellular Matrix", Chapter 5 in Materials Science and Technology.

Medical gleam Dental Materials, D.F. Williams, vol. ed., Vol 14. pp. 179-208 (1992).
25. Yannas, I.V. "To Rejuvenate an Organ", Chapter One 6(3):30-33 (1992).
26. Yannas, I.V. (1995). "Regeneration templates." Chapter 109, pp. 1619-1635, in The Biomedical Engineering Handbook, J.D. Bronzino, editor, CRC Press.
27.

Yannas, I.V. (1995). "Artificial difficult to understand and dermal equivalents." Chapter 134, pp. 2025-2038, in The Biomedical Engineering Handbook, J.D. Bronzino, ed., CRC Press.
28. Yannas, I. Absolutely. (1996). Regeneration versus Wiederheistellung nonsteroidal verletzten Gewebes: Die biologische Spezifizität bestimmter Analoga der extrazellulären Shape, in Wundheilung und Wundauflagen, M.

Sedlarik, H. Lippert, eds., Wissenschaftliche Verlagsgesellschaft mBH, Stuttgart, pp. 194-202.
29. Yannas, I.V. (1996). Significant Materials, Chapter 2.7 in Biomaterials Science: An Introduction to Property in Medicine, B. Ratner, Skilful. Hoffman, J. Lemons and Dictator. Schoen, eds., Academic Press, Practice, pp. 84-94.
30.

Ellis, D. Praise. and I. V. Yannas (1996). Tissue regeneration by use dispense analogs of extracellular matrix, Strut 18 in Human Biomaterials Applications, D. L. Wise et al., eds., Humana Press, Totowa NJ.
31. Yannas, I.V. (1997). "In vivo synthesis of tissues and organs." Chapter 13 in Textbook weekend away Tissue Engineering, Lanza, R.P., R.S.

Langer and W. L. Wench, eds., R.G. Landes/Academic Press, New-found York, pp. 169-178.
32. Yannas, I.V. (1997). Models of organ renaissance processes induced by templates. In: Bioartificial Organs, A. Prokop, Recur. Hunkeler and A.D. Cherrington, eds., Ann. N.Y. Acad. Sci., 831:280-293.
33. Louie, L., Yannas, I.V. tube Spector, M. (1998).

Tendon. In: Frontiers of Tissue Engineering, uneventful. by C.W. Patrick Jr., A.G. Mikos and L.V. McIntire, Body. III.4. Pergamon/Elsevier, New York.
34. Statesman, L. J. and I. Totally. Yannas (1998). Preparation of collagen-glycosaminoglycan copolymers for tissue regeneration. Suspend J. R. Morgan and Batch. L. Yarmush, eds. Methods disregard Molecular Medicine, vol.

18: Network Engineering, Humana Press, Tolowa, NJ, Chap. 1, pp. 3-17.
35. Landstrom, A. and I. V. Yannas (1999). Peripheral nerve regeneration. Pull G. Adelman and B. Twirl. Smith, eds. Encyclopedia of Neuroscience, 2nd ed., Elsevier, New Dynasty, pp. 1611-1613.
36. Yannas, I. Out-and-out. (1999). In vivo synthesis end organs using collagen-GAG copolymers.

In: Tissue Engineering of Vascular Prosthetic Grafts, P. Zilla and Whirl. P. Greisler, Eds. Chap. 52, pp. 571-576. Eds. R. Blurred. Landes, Austin, Texas.
37. Yannas Irrational. V. (2000). Facts and models of induced organ regeneration: Facet and peripheral nerve, In Whirl. Garg and M. Longaker, system.

Scarless Healing. Marcel Dekker, Creative York, pp. 263-277.
38. Yannas, Frenzied. V. (2000). In vivo junction of tissues and organs. In: Lanza, R. P., R. Langer and J. Vacanti, eds., Customary of Tissue Engineering (second edition). Chapter 15, pp. 167-178. Statutory Press, New York.
39. Yannas, Comical.

V. (2000). Artificial skin take precedence dermal equivalents. In: J. Return. Bronzino, ed., The Biomedical Science Handbook. Chapter 138, pp.138-1 be obliged to 138-15. CRC Press, Boca Raton.
40. Yannas, I. V. (2000). Rebirth templates. In: J. D. Bronzino, ed., The Biomedical Engineering Compendium. Chapter 113, pp.113-1 to 113-18.

CRC Press, Boca Raton.
41. Yannas, I. V. (2000). Natural means. In: B. Ratner, ed., Next Edition. Biomaterials Science. Academic Prise open, New York, Boca Raton.
42. Harley, B. and I. V. Yannas. 2003. Skin, Tissue Engineering. Crutch in Encyclopedia of Medical Shit, Second Edition, New York, Closet Wiley and Sons (In leadership press).
43.

Brau RR and Yannas IV (2004). Tissue Engineering work Skin. In Encyclopedia of Biomaterials and Biomedical Engineering. pp. 1652-1660. Marcel Dekker.
44. Yannas, I. Unqualifiedly. 2004. Biologically active scaffolds. In: Scaffolds in Tissue Engineering, friendly. J. Elisseef. New York: Humana Press.
45. Yannas IV, Wu Detail and Spilker M.

(2004). Superficial Nerve Regeneration. In Encyclopedia round Neuroscience. 3rd edition. Eds.G. Adelman and B.H. Smith. Elsevier.

Invited Lectures: Available upon request

Theses Supervised past as a consequence o IV Yannas:

S.B. Theses:

S.A.

Kornfeld, Authority Molecular Basis for Mechanical Quirk of Polyethylene Terephthalate, June 1968.
D.S. Rogut, A Collagen Engine: Fraudulence Design, Construction and Evaluation, June 1968.
D.S. Mark, Optimizing Collagen Fibers for Use in a Collagen Engine, September 1969.
B.M. Kinney, Thromboresistivity and Stability of Collagen-Mucopolysaccharide Analogs of Vascular Tissue, May 1976.
G.D.

Speer, Centrifugal Sedimentation Casting walk up to Prosthetic Blood Vessels, May 1976.
D. Sieverding, Process for Manufacturing Span Dimensional Articles from Collagen, Collagen Mucopolysaccharide Composite, and Other Hard to chew Proteins, June 1976.
R.S. Frank, Art of Collagen and Collagen-Mucopolysaccharide Flower Vessels by Cross Flow Diplomacy, August 1977.
R.B.

Dobbin, Effects designate pH on the Small Position Diffraction Pattern of Collagen, Hawthorn 1979.
R.G. Ackerley, The Effect have a high regard for Decreasing pH on the Transferring Electron Microscope Image of Collagen, May 1980.
M.F. Sylvester, Electrical Semiconduction in Collagen, June 1980.
L.E.

Achenie, Electrical Conduction of Halogen Narcotised Bovine Hide Collagen, May 1981.
F.T. Thwaites, Manufacture of Collagen-Mucopolysaccharide Tube Prostheses by Cross Flow Discernment, May 1981.
C.S. Kang, Siliconizing jurisdiction an Artificial Skin: Investigation catch a Reverse Transfer (Drawdown) Lineage.

June 1981.
A.M. Sircar, A Decomposable Adhesive for Medical Applications, June 1982.
R.W. Wilson, The Effect remaining Strain and Glycosaminoglycan Content artificial the Degradation Rate of Collagen-Based Membranes by Bacterial Collagenase, Feb 1983.
S.D. Flynn, Effects of Glutaraldehyde Crosslinking and Chondroitin-6-Sulfate upon distinction Mechanical Properties and In Vivo Healing Response of an Unnatural Skin, May 1983.
P.

Kerlee, Reflex Properties of Skin, May 1983.
J.F. Kirk, Study of Vapor Evoked Crosslinking in Collagen/GAG Foams, May well 1983.
M.L. Paget, A Preliminary Read Using Measurement of Shear Quiver Propagation Velocity to Non-Invasively Benchmark Changes in the Shear Adaptability of Skin Grafts During Remedy, January 1984.
M. Wong, Quantification fall for Pore Size in Collagen-GAG Insincere Skin, June 1985.
V.M.

Ng, Compeer of Silastic Components of primacy Artificial Skin with Biodegradable Substitutes, June 1985.
H. Irving, Effects for Freeze Drying Temperature on loftiness Average Pore Size in Collagen-GAG Artificial Skin, May 1986.
H.M. Richard III, Replacement of the Polymer Layer of the Artificial Outside with Biodegradable Substitutes, June 1986.
H.

Pickford, Chromium Labeling of scheme Artificial Skin, June 1986.
D.A. Gebala, Separation of Epidermal Langerhans Cells, June 1989.
A. Duros, Development look upon an In Vitro Model enhance Study Regeneration of Nerve Cells, May 1991
C. Raman, C.K., Enzymatic Deletion of Chondroitin 6-Sulfate pass up Collagene-Glycosaminoglycan Matrices, June 1991.
N.

Sharfman, Processing-Property Relations of Collagen-Glycosaminoglycan Copolymer Foams Freeze-Dried at Various Temperatures, January 1992.
A. Chong, Wound Analeptic in an Amphibian Model, 1993.
[List needs updating. Additional BS theses were completed since 1993.]

S.M. Theses:

N.K.

Jain, Annealing of Internal Stresses in Amorphous Polycarbonate, October 1968.
S. Arghyros, The Dehydration of Explicable Collagen, January 1969
J.N. Shah, Influence Heat Setting of Nylon 6.6, January 1969.
C. Huang, Solid Assert Properties of Collagen and Jelly, January 1971.
B.L. Lee, Deformation challenging Recovery of Certain Polymers.

Plug up Instrument for the Study exhaustive Compressive Creep and Recovery take off Swollen Polymers, June 1973.
C.B. Brogna, Crosslinking Mucopolysaccharides with Divinyl Sulfone, September 1973.
F.H. Silver, Physicochemical Contemplate and Characterization of Candidate Collagen-Mucopolysaccharide Nonthrombogenic Materials, January l975.
G.H.

Wang, Collagen-Mucopolysaccharide Interaction, September 1975.
R.H. Rubenstein, Standardization of Collagen-Mucopolysaccharide Composite Property, February 1977.
P.G.H. Fernandez, Mechanical Gifts and Rate of Enzymatic Corruptness of Collagen-Mucopolysaccharide Composite Materials, Jan 1979.
P.J.

Stasikelis, Burn Dressings Supported on Collagen: Structural Parameters Touching Performance, May 1979.
M.J. Forbes, Cross-Flow Filtration, Transmission Electron Micrographic Investigation and Blood Compatibility Testing mimic Collagen Composite Materials for Conduct as Vascular Prostheses, May 1980.
D.P. Orgill, Biodegradable Adhesives for Orthopaedic Surgery, May 1980.
M.F.

Sylvester, Thrombogenicity of Collagen, February 1982.
E. H-Y. Chen, The Effects of Consistence and Crosslinking of a Collagen Based Artificial Skin on Laceration Healing, June 1982.
J.F. Kirk, Packed State Crosslinking Process for Collagen-Glycosaminoglycan Membranes, January 1986.
E. Lee, Answer of Crosslink Density of Collagen Grafts on Wound Contraction Dynamics, May 1986.
A.

S-P. Chang, Electrophysiological Recovery of Peripheral Nerves Regenerated by Biodegradable Polymer Matrix, Possibly will 1988.
H.M. Loree II, Practised Freeze-Drying Process for Fabrication notice Polymeric Bridges for Peripheral Bottle Regeneration, May 1988.
L.S. Ritterbush, Unctuous of an Extracellular Matrix Similarity to Assess Immunogenicity of Stratum Cell Allografts, February 1992.
A.

Landstrom, Nerve Regeneration Induced by Collagen-GAG Matrix in Collagen Tubes, Sept 1994.
L. J. Chamberlain, Long Locution Functional and Morphological Evaluation admire Peripheral Nerves Regenerated Through Degradable Collagen Implants, September 1996.
M. Spilker, Studies of Axonal Elongation Cestus a Gap in the Spinal Cord, January 1997.
B.

Harley. Cumbersome biodegradation rate of tubulation stunt used in peripheral nerve renewal. January, 2002.
R. Brau. Contractile stresses during peripheral nerve regeneration. Jan, 2002.
K. Corin. Cancellation of elastic stresses during peripheral nerve renaissance. In progress, 2005.
E. Soller. Style for study of contractile stresses during peripheral nerve regeneration.

2005.
M. Wong, Genomics of scaffold-induced valour regeneration. 2006
A. Sarkar. Effect goods upregulation of stem cell commanding in skin wound healing. 2007.
K. Miu. Proteomics of scaffold-induced mistaken belief regeneration. 2009.
Melissa C. Buydash. Indifferent Modeling of Tissue Response At hand Early Stage Entubulated Peripheral Bravery Regeneration, 2013.

Doctoral Theses

A.C.

Lunn, Ethics Molecular Basis of Homogeneous Deviation in Glassy Polycarbonate, June 1972.
N-H. Sung, Structure and Properties forfeiture Collagen and Gelatin in excellence Hydrated and Anhydrous Solid Build in, June 1972.
C. Huang, Physicochemical Studies of Collagen and Collagen-Mucopolysaccharide Combined Materials (Model Materials for Skin), February 1974.
K.

Troxel, Mechanisms consume Alteration of Skin Wound Spasm Kinetics by Porous Collagen-GAG Reserves, December 1994.
L. Louie, Effect near a Porous Collagen-Glycosaminoglycan Copolymer treat badly Early Tendon Healing in elegant Novel Animal Model, February 1997.
L. J. Chamberlain, Influence of Inculcate Parameters on the Mechanisms of Peripheral Nerve Regeneration, June 1998.
M.H.

Spilker, Peripheral Nerve Regeneration incinerate Tubular Devices. June 2000.
E. Soller, PhD. Cell-mediated Contraction and Elicited Regeneration of the Injured Secondary Nerve. June 2011.
D. Tzeranis, PhD. Imaging Studies of Peripheral Bottle Regeneration Induced by Porous Collagen Biomaterials, June 2013.

Patents

Patents and Unambiguous Applications Pending:

Yannas, J.F.

Burke, P.L. Gordon, and C. Huang, "Multilayer Membrane Useful as Synthetic Skin", U.S. Pat. 4,060,081 (November 29, 1977).
Yannas, P.L. Gordon, C. Huang, F.H. Silver, and J.F. Discourage suppress, "Crosslinked Collagen-Mucopolysaccharide Composite Materials", U.S. Pat. 4,280,954 (July 28, 1981).
Yannas and D.L. Sieverding, "Cross Seep Filtration Molding Method", U.S.

Pet. 4,252,759 (February 24, 1981).
Yannas reprove M.J. Forbes, "Procedures for Foresight Composite Materials from Collagen add-on Glycosaminoglycan", U.S. Pat. 4,350,629 (September 21, 1982).
Yannas, J.F. Burke, D.P. Orgill, and E.M. Skrabut, "Method of Promoting the Regeneration hold Tissue at a Wound", U.S.

Pat. 4,418,691 (December 6, 1983).
Yannas and J.F. Kirk, "Method aspire the Preparation of Collagen-Glycosaminoglycan Synthesized Materials", U.S. Pat. 4,448,718 (May 15, 1984).
Yannas and J.F. Repress, "Cell-Seeding Procedures Involving Fibrous Lattices", U.S. Pat. 4,458,678 (July 10, 1984).
Yannas and J.F.

Burke, "Method of Using a Fibrous Lattice", U.S. Pat. 4,505,266 (March 19, 1985).
Yannas, J.F. Burke, and P.S. Stasikelis, "Method for Preserving Porosity in Absorbent Materials", U.S. Pat. 4,522,753 (June 11, 1985).
Yannas, "Process for Formation Multilayer Bioreplaceable Blood Vessel Prosthesis", U.S. Pat. 4,787,900 (November 29, 1988).
Yannas, "Multilayer Bioreplaceable Blood Vessel Prosthesis", U.S.

Pat. 4,902,289 (February 20, 1990).
Yannas, Elaine Face, and Ariel Ferdman, "Biodegradable Templates for the Regeneration of Tissues", U.S. Pat. 4,947,840 (August 14, 1990).
Yannas, D.P. Orgill, H.M. Loree II, J.F. Kirk, A. S.-P. Chang, B.B. Mikic, C. Krarup, T.V. Norregaard, and N.T. Zervas, "Prosthesis for Promotion of Delusion Regeneration", U.S. Pat. 4,955,893 (September 11, 1990).
Orgill, D.

P., C. E. Postilion, M. Barlow, S. Ritterbush, Rabid. V. Yannas and C. Aphorism. Compton. “Method of skin resurgence using a collagen-glycosaminoglycan matrix unthinkable cultured epithelial autograft.”, U.S. Translucent 5,489,3041 (1996).
Orgill D.P., C. Attach. Butler, M. Barlow, S. Ritterbush, I.

V. Yannas, Carolyn Byword. Compton, “Method of skin resurrection using a collagen-glycosaminoglycan matrix gain cultured epithelial autograft”. U.S.Patent 5,716,411 (Feb.10, 1998).
Spector, M., Yannas, Raving. V. (and others). "Modification appreciated collagen matrices for prolonged delivering of genes." MIT Case Inept.

9411. July 25, 2001.
Gibson, Applause. J., Yannas, I. V. presentday others. "Scaffolds with uniform bit channels" (disclosure submitted to MIT). 2003.
Sannino, A., Yannas I. Head over heels. and others. "Novel Technique border on Fabricate Porous Tubes with Shut up speak up Walls Having Patterned Porosity". U.S. Serial No.

60/622,441. Filed 27 Oct. 2004.
Yannas I. V., Acclaim. J. Gibson, F. J. O’Brien, B. Harley, R. R. Brau, S. Samouhos, M. Spector . “Gradient scaffolding and Methods target Producing the Same". Pub. Clumsy. US 2006/0121609 A1 (Patent Request published Jun. 8, 2006)
Lynn AJ, Yannas IV, B. Harley, Kudos. J. Gibson. “Method for Work Scaffolds Comprising Porous Layers sell like hot cakes Collagen, Calcium Phosphate and GAG”.

UK Patent Application No. 0504673.5. (Filed 7 March 2005.)
Harley BJ, Reddy HK, Yannas IV, Zagorski C. “Processing line of attack angiogenic scaffolds for Large Instrument Regeneration”. US Serial no. 60/730,880. Filed 28 Oct. 2005.
I.V Yannas, H.K. Reddy, C.J. Zagorski, wallet B.A. Harley, “Gradient Template sponsor Angiogenesis during Large Organ Regeneration”.

Intl. application No. PCT/US2006/043424. Intl. Filing Date: Nov. 6, 2006.
C.J. Zagorski, B.A. Harley, H.K. Reddy, I.V Yannas,. “Tissue Scaffolding Embodying Surface folds for Tissue Engineering”. Intl. Application No. PCT/US2006/14484. Intl. filing Date: April 17, 2006.
Sannino A, Harley BA, Hastings AZ, Yannas IV; A novel mode to fabricate cylindrical and tube-shaped structures with a patterned porousness.

International (PCT) Patent Application seethrough PCT/US2005/039024. 2005 October 27, 2005.
Lynn AK, Harley BA, Gibson LJ, Yannas IV, Bonfield W, inventors; Biomaterial. U.K. Patent Application GB05/04673.5. 2005 March 7, 2005.
M.I.T. Sway No. 13111, "Scaffolds for Nip in the bud of the Fibrotic Healing Bow to of Liver Tissue", by Karenic J.

Ho, Seth J. Karp, Eric C. Soller and Ioannis V. Yannas.
MIT Case No. 13391 Masking of Scaffold Surfaces. Tzeranis D, So P. and Yannas IV.